Avid Bioservices Inc (CDMO)

[jazzbeerman]

SP, re: Crucell's PER.C6 & Peregrine/Avid ---------


IMHO,

If the govt funded work goes well and the govt were considering "stockpiling" Bavi or any of its future anti-PS offspring, (or even simply expected needing a lot of it for the 5 yr's of experiments), the best current expression system to make the stuff - by far - would be PER.C6.



It's INCREDIBLY high-yield.

and-

It's been through the wringer... it's been around a long long time. It's as safe as it gets.

It sure does make one wonder why Avid wound up being the FIRST U.S. production plant using Crucell PER.C6 to crank out mabs etc...


Personally, I think it could be related to either the govt expecting to order a lot of bavi/humanized anti-PS (if the work goes AS WELL AS IT ALREADY HAS in the Pichinde and CMV experiments), or CHAVI /Gates expecting to order a lot of the stuff.

or both.


here- this is a brief pdf with a little info on PER.C6 -
http://www.crucell.com/page/downloads/Factsheet_PER.C6_June2008.pdf




j

Haynes patent application --------

1. A method of treating HIV comprising administering to a patient in need thereof an antibody derivable from an normal subject or from an autoimmune disease subject that binds to a lipid on the surface of HIV or on the surface of HIV-infected cells and thereby neutralizes HIV-1, wherein said antibody is administered in an amount sufficient to effect said treatment.

2. The method according to claim 1 wherein said antibody is derivable from an anti-phospholipid syndrome subject.

3. The method according to claim 1 wherein said antibody is non-pathogenic.

4. The method according to claim 1 wherein said antibody is IS1, IS4 or IS6, or binding fragment thereof.

5. The method according to claim 1 wherein said antibody is IS1, or binding fragment thereof.


[0108] Alving and colleagues have made a mouse mab against phosphatidyl inositol phosphate and have shown that it neutralizes HIV in a PBMC assay. What the present studies show is that humans can spontaneously make anti-lipid antibodies and that these antibodies can broadly neutralize HIV in an unprecedented manner.



[0109] Summarizing, autoimmune disease patients can make antibodies that bind to virus-infected cells and, presumably, to budding HIV virions by virtue of their reactivity to HIV membranes and host membranes. Certain anti-lipid antibodies from autoimmune disease patients can also react with the Envelope trimer (such as IS6) but not all of the antibodies react also with the trimer (i.e., IS1 and IS4 do not react). Therefore, reactivity with the HIV envelope is not a prerequisite for neutralization in these antibodies.


AND MY FAVORITE SNIP!!!!!!!!!!! -

[0051] It will be appreciated from a reading of the foregoing that if HIV has evolved to escape the host immune response by making the immune system blind to it, other infectious agents may have evolved similarly. That is, this may represent a general mechanism of escape. That being the case, approaches comparable to those described herein can be expected to be useful in the treatment of such other agents well.



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