Protherics plc (PTIL)

[RobinSLCC]

Press Release Source: Protherics PLC


Protherics PLC - Rule 2.10 Announcement
Thursday August 14, 4:41 am ET


CHESHIRE, UK--(MARKET WIRE)--Aug 14, 2008 --



Protherics PLC

Rule 2.10 Announcement


London, UK; Brentwood, TN, US; 14 August 2008

In accordance with Rule 2.10 of the City Code on Takeovers and Mergers
(the "Code"), Protherics confirms that at the close of business
on 13 August 2008, it has 342,159,034 ordinary shares of 2 pence each
in issue and admitted to trading on the London Stock Exchange under the
UK ISIN code GB0007029209.

The ISIN number above corrects that cited in the Rule 2.4 announcement
issued by the Company on 13 August 2008.


ENDS


For further information please contact:


Protherics [phone]
Andrew Heath, CEO
Rolf Soderstrom, Finance Director
Nick Staples, Director of Corporate Affairs

Jefferies International Ltd.
Ian Crosbie [phone]

Nomura Code Securities Ltd.
Chris Collins [phone]

Financial Dynamics - press enquiries
Ben Atwell [phone]



Or visit http://www.Protherics.com


Dealing Disclosure Requirements

Under the provisions of Rule 8.3 of the Code, if any person is, or
becomes, interested" (directly or indirectly) in 1% or more of any
class of "relevant securities" of Protherics, all "dealings" in
any"relevant securities" of that company (including by means of an option
in respect of, or a derivative referenced to, any such "relevant
securities") must be publicly disclosed by no later than 3.30 pm
(London time) on the London business day following the date of the
relevant transaction. This requirement will continue until the date on
which the offer becomes, or is declared, unconditional as to
acceptances, lapses or is otherwise withdrawn or on which the "offer
period" otherwise ends. If two or more persons act together pursuant to
an agreement or understanding, whether formal or informal, to acquire
an "interest" in "relevant securities" of Protherics, they will be
deemed to be a single person for the purpose of Rule 8.3.

Under the provisions of Rule 8.1 of the Code, all "dealings" in"relevant
securities" of Protherics by a potential offeror, or
by Protherics, or by any of their respective "associates", must be
disclosed by no later than 12.00 noon (London time) on the London
business day following the date of the relevant transaction.

A disclosure table, giving details of the companies in whose "relevant
securities""dealings" should be disclosed, and the number of such
securities in issue, can be found on the Takeover Panel's website at
http://www.thetakeoverpanel.org.uk."Interests in securities" arise, in summary,
when a person has long
economic exposure, whether conditional or absolute, to changes in the
price of securities. In particular, a person will be treated as having
an "interest" by virtue of the ownership or control of securities, or
by virtue of any option in respect of, or derivative referenced to,
securities. Terms in quotation marks are defined in the Code, which can
also be found on the Panel's website. If you are in any doubt as to
whether or not you are required to disclose a "dealing" under Rule 8,
you should consult the Panel.