Avid Bioservices Inc (CDMO)

[jazzbeerman]

Haynes quote from Duke PR about his recent microparticle paper -------------




Bart Haynes: (re: HIV vaccine design)

"It is becoming clearer why we have failed in our efforts to date, and what we need to confront to succeed in the future."

http://www.dukemednews.com/news/article.php?id=10364



.......


"Researchers also examined the effects of cell death products upon B cells, another arm of the immune system responsible for the creation of antibodies. Previous studies have shown that the antibody response to HIV-1 is "too little, too late" – appearing after the virus has peaked and after the reservoir of infected T cells has already been established.

Through a series of in vitro laboratory experiments with peripheral blood cells, scientists found that microparticles suppressed levels of IgG and IgA, two classes of antibodies that normally would protect a person against infection. "This is important because many scientists believe that a fast-acting memory B cell response as well as a T cell response will be necessary to fight HIV-1" said Nancy Gasper-Smith, PhD, the lead author of the study."



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