Protherics plc (PTIL)

[surf1944]

Protherics PLC announces Holding(s) in Company - 1
Friday June 13, 1:11 pm ET

Cheshire, UK--(MARKET WIRE)--Jun 13, 2008 --

Protherics PLC

Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 13 June 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that today, in
accordance with the Transparency Obligations
Directive, a notification of interest in the ordinary share capital of
the Company was received from Invesco Perpetual on behalf of Perpetual
Income and Growth Investment Trust. Details of
the interest notified are as follows:

1. Reason for the notification (please tick the appropriate box or
boxes)

An disposal of voting rights Yes

An acquisition or disposal of financial instruments which may
result in the acquisition of shares already issued to which voting
rights are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the Perpetual Income and
notification obligation: Growth Investment
Trust

3. Full name of shareholder(s) (if different from 2.):

4. Date of the transaction (and date on which the 12 June 2008
threshold is crossed or reached if different):

5. Date on which issuer notified: 13 June 2008

6. Threshold(s) that is/are crossed or reached: crossed 4% threshold
into 3%

7. Notified details:



A: Voting rights attached to shares

Class/type of Situation previous Resulting situation after the triggering
shares to the Triggering transaction
transaction
if possible
using the ISIN Number of Number of Number of Number of voting % of voting
CODE Shares Voting shares rights rights
Rights
Direct Indirect Direct
Indirect
14,348,079 14,348,079 13,568,085 13,568,085 3.98%
Ordinary 2P
Shares
(GB0007029209)




B: Financial Instruments

Resulting situation after the triggering transaction

Type of Expiration Exercise/ Number of voting rights that % of
financial date Conversion may be acquired if the voting
instrument Period/ instrument is exercised/ rights
Date converted.




Total (A+B)

Number of voting rights % of voting rights


13,568,085 3.98%



8. Chain of controlled undertakings through which the voting rights and
/or the financial instruments are effectively held, if applicable :

Name of Company/Fund Number of % of issued
Shares share capital


Citibank 13,568,085 3.98%



Proxy Voting:

9. Name of the proxy holder:



10. Number of voting rights proxy holder will cease to hold:



11. Date on which proxy holder will cease to hold voting rights:



12. Additional information:




/ Ends /


For further information please contact:


Protherics

Nick Staples, Director of Corporate Affairs [phone]

Julie Vickers, Company Secretary [phone]


Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott [phone]

New York: John Capodanno, Jonathan Birt [phone]



Or visit http://www.protherics.com

This information is provided by RNS
The company news service from the London Stock Exchange

END




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