Avid Bioservices Inc (CDMO)

[jazzbeerman]

Free - nice find! WOW!!



I've been waiting for that one!

That's likely got the details (and then some) of what Haynes was discussing when he was the Plenary speaker at the Gates vaccine conf. last August.

Remeber the abstract for that one -







Now we see this today -



J. Virol.

JVI Accepts, published online ahead of print on 28 May 2008

Induction of Plasma (TRAIL), TNFR-2, Fas Ligand and Plasma Microparticles After HIV-1 Transmission: Implications for HIV-1 Vaccine Design


Nancy Gasper-Smith, Deanna M. Crossman, John F. Whitesides, Nadia Mensali, Janet S. Ottinger, Steven G. Plonk, M. Anthony Moody, Guido Ferrari, Kent J. Weinhold, Sara E. Miller, Charles F. Reich III, Li Qin, Stephen G. Self, George M. Shaw, Thomas N. Denny, Laura E. Jones, David S. Pisetsky, and Barton F. Haynes*


Duke Human Vaccine Institute, Departments of Medicine, Surgery, Immunology,
and Pathology, Duke University School of Medicine, Durham, NC 27710;
Durham VA Hospital, Durham, NC 27710;
Fred Hutchinson Cancer Research Center, Seattle, WA 98109;
Statistical Center for HIV/AIDS Research and Prevention, (SCHARP), Seattle, WA, 98109;
University of Alabama-Birmingham, Birmingham, AL 35223; and
Department of Ecology and Evolutional Biology, Cornell University, Ithaca, NY 14853


Abstract

Death of CD4+, CCR5+ T cells is a hallmark of human immunodeficiency virus infection. We studied the plasma levels of cell death mediators and products – tumor necrosis factor-related apoptosis inducing ligand (TRAIL), Fas ligand, tumor necrosis factor receptor type 2 (TNFR2) and plasma microparticles during the earliest stages of infection following HIV-1 transmission in plasma samples from US plasma donors. Significant plasma TRAIL elevations occurred a mean of 7.2 days before the peak of plasma viral load (VL), while TNFR2, Fas ligand and microparticle elevations occurred coincident with maximum VL. Microparticles have been previously shown to mediate immunosuppressive effects on T cells and macrophages. We found that T cell apoptotic microparticles also potently suppressed in vitro IgG and IgA antibody production by memory B cells. Thus, release of TRAIL during the eclipse phase of HIV-1 transmission may initiate or amplify early HIV-1 induced cell death. The window of opportunity for a HIV-1 vaccine is from HIV-1 transmission until establishment of the latently infected CD4+ T cells. Release of products of cell death and subsequent immunosuppression following HIV-1 transmission could potentially narrow the window of opportunity in which a vaccine has to plausibly extinguish HIV-1, and place severe constraints on the time the immune system has to respond to the transmitted virus.


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That's huge.

They are saying that PS-exposing microparticles shut off effective responses from T cells, and macrophages, and B cells

!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

and it's from some big CHAVI names. (Haynes, Self, Shaw, etc.)

They're on board the PS immunosuppressive train.

CHAVI's vaccine work is paving the way to what I expect to be the most effective HIV therapeutic ever....

Actually- CHAVI's vaccine work is paving the way to what I expect to be the most effective broad-spectrum antiviral drug ever...

and yes, I expect it to be anti-PS from Peregrine Pharmaceuticals.


This is incredibly exciting.



They basically laid out their hypothesis last January in this illustration:






How did they plan to deal with the immunosuppressive PS, which also happens to be a target on the virus?

IMHO -






it's happening :)

j