Avid Bioservices Inc (CDMO)

[jazzbeerman]

terry,


There has yet to be a published paper on Thorpe's anti-PS viral work. I think we'll see it soon though. Also, as jessme suggested, it may be published concurrently with a separate paper out of Duke on their work with Peregrine's mabs. That would not surprise me. It would be great to see both papers in a top journal, and frankly, I expect it, due to the importance of the discoveries.

Thorpe's grant was up on Jan 31, 2008. You can read about the original info on the grant, with a brief outline of the proposed work, here at the CRISP database, if you go to the querry form, and put thorpe's name into the field,

http://crisp.cit.nih.gov/


Notice that the work culminates with experiments using the real lassa fever virus in a biosafety level 4 lab in Galveston TX.

"Key findings will then be validated for Lassa fever virus itself and with other arenaviruses that cause hemorrhagic fevers in a BSL-4 containment facility at UTMB Center for Biodefense, Galveston."

Well, the director of that lab, Clarence J. Peters, is now listed on Peregrine's SRB,



ANTI-VIRAL – HEMORRHAGIC FEVER

Daniel G. Bausch, M.D., M.P.H.
Associate Professor, Department of Tropical Medicine, Tulane School of Public Health and Tropical Medicine, New Orleans LA


Clarence J. Peters, M.D.
University of Texas Medical Branch, Galveston, TX
Director, Center for Biodefense
Professor of Pathology and of Microbiology and Immunology
Director of the Biosafety Level 4 Laboratory
WHO Collaborating Center for Tropical Diseases
Member

http://www.peregrineinc.com/index.php?option=com_content&task=view&id=15&Itemid=29


There is indeed an upcoming anti-PS viral paper out of UTSW, as mentioned in this slide at a recent Peregrine presentation in New York -




I expect the upcoming Thorpe viral paper to include the things we already know as well as new info. (Things we know like the in vitro work investigating anti-PS binding to all enveloped viruses, anti-PS preventing viral infection of cells, anti-PS binding to virus infected cells, the lassa fever guinea pig experiment, the CMV mice experiment, etc.)

I also expect the Thorpe viral paper to include many new things, obviously for instance the work from the BSL4 lab in Galveston, but also I'm expecting new influenza data and other data, namely - "other arenaviruses that cause hemorrhagic fevers" as mentioned in he grant...

It should be very exciting.

and again, I wouldn't be surprised to see it come out along with the paper out of Duke, both in a "top" journal, and get major press...


JMO,


j