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Friday, May 16, 2008 8:44:13 AM
I suspect we might have differing opinions on ELN- consider the following:
i) ELN trades at over 13x this year's revs while BIIB trades at 4x and BIIB makes money- if you want to own Tysabri why not own BIIB- they have the same enterprise value (market cap plus debt less cash) but with BIIB you get profitability, Avonex and Rituxan.
ii) This alzheimers trial has less than a 5% chance of working. WYE originally stated that they would only start a PIII if the PII interim look was close to stat sig or trend or whatever. then in WYE erns call they said they started a PIII based on PII results, their belief in their scientists and immunology platform and a large unmet medical need- sounds very watered down to me
iii) why is the PIII trial design 40x ish larger than PII if signal from PII was so clean?
iv) what the hell is going on with the endpoints BS?
v) why is ELN not letting certain people into their investor day? last company this happened with i know of was hiding something.
vi) Tysabri numbers from analyst estimates are coming down
vii) the recent report out yesterday from Caris is decent in that if this alz trial fails stock is worth teens at best.
viii) wildcard- what happens if a problem occurs with tysabri again?
ix) sentiment is in the stratosphere- last stock i saw sentiment this high in and i was short it was IMA in the 60s (they had a lot of problems like 7x debt/ebitda, overpaying for acquisitions, no core organic growth)- i basically told Mark Richter from Jefferies that he was dead wrong on this- stock hit 20s a few months later and that guy no longer shows up at Jefferies (did he lose his job over that shitshow?).
Careful.
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