Nuvo Research Inc (MRVFF)

[BioSpecialist]

"Pennsaid on track to be best in class FDA approved topical NSAID for osteo-arthritis"

Nuvo Research (NRI.TO)


Marketcap: 35 Million C$
Cash: 19,1 Million C$
Price: 0,12 C$


Please read
http://www.nuvoresearch.com/documents/2007%20-%20Investor%20Presentation.pdf


Nuvo announces first quarter 2008 financial results
Thursday May 1, 7:00 am ET
http://biz.yahoo.com/cnw/080501/nuvo_q1_2008_results.html?.v=1
Key Corporate Developments:

- Pennsaid product sales more than tripled to $1.7 million;
- Successful launch continued in Greece with Pennsaid capturing over
30% of its market during the first quarter, placing it first in
its class by revenue;
- The Company continued to make substantial progress regarding the
studies to be provided to the FDA to address the conditions raised
in the Approvable Letter for Pennsaid, a topical non-steroidal
anti-inflammatory drug (NSAID) used to treat the pain and
stiffness associated with knee osteoarthritis (OA); and,
- The Company believes it will be in a position to file a complete
resubmission of its Pennsaid application to the FDA in early 2009
and be eligible to receive final marketing approval six months
later.

"We are extremely optimistic about Nuvo's future. We have a post-Phase III
product that is unlicensed for the large and growing U.S. OA market and we
remain confident that we will be in a position to file a complete resubmission
of our application for Pennsaid approval in early 2009," said Henrich
Guntermann, President and Chief Executive Officer, "In addition, our high
throughput screening and MMPE technology is creating a promising pipeline of
transdermal drug candidates."



Fighting arthritis with exercise and Pennsaid
Provided by: Sun Media

'Why are you using Celebrex, an oral nonsteroidal anti-inflammatory drug (NSAID) to treat arthritis of your knee when a safer medication, Pennsaid, is available? And a new report from Boston will also help to ease your pain."

This is the advice I recently gave my tennis partner.

Several years ago in my book, The Healthy Barmaid, I told the story of a patient whose arthritic fingers were improved by playing the piano. For years, I've been convinced that many people would not require hip and knee replacements if they used their legs more.
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But a report from Boston claims that once arthritis sets in, walking isn't the entire answer. Dr. Ronenn Roubenoff, a rheumatologist at Tuft's University, says it also depends on the type of exercise.

He claims that few people realize the enormous pressures to which the joints are subjected. Amazingly, for every pound we weigh, a single step creates three pounds of pressure across the knees and hips.

VICIOUS CYCLE

This can be a problem therefore when the doctor says, "You've got to walk more." Rather than helping the pain, the knee hurts more and patients stop walking. This creates a vicious cycle. Inactivity leads to further weight gain, and more pressure on the knees causes more pain. It's a lose-lose situation.

Dr. Roubenoff says specific exercise is needed to strengthen the muscles which act like the shock absorbers of a car. We know we feel every bump in the road if our car's shock absorbers wear out. And this is what happens to joints if muscles are weak.

Fortunately Dr. Roubenoff's program needs no expensive equipment nor the worry of Draconian exercise. Leg muscles are strengthened by simply sitting in a chair and repeatedly getting up and down.

Another exercise involves placing increasing weights on the extended leg while sitting in a chair and moving the knee up and down. Dr. Roubenoff's patients were asked to do this twice a week.

By the end of 16 weeks, his patients had increased muscle strength by 71%. Now many could walk up and down stairs, sleep better and pain was decreased by 43%.

However, to achieve this end, Dr. Roubenoff insisted it's mandatory to push muscles beyond their current limits. This is what eventually makes the muscles more powerful. And if patients have the motivation to do so, they do not have to blindly accept the diagnosis of chronic arthritic pain.

A recent Harvard study, however, reported that rheumatoid specialists only recommended exercise in 50% of cases of rheumatoid arthritis. And a study in Canada showed that family doctors prescribed exercise to only one-third of patients with arthritis of the knee.

Today, many patients are taking Celebrex, Vioxx and other oral NSAIDs to treat arthritis of the knee. But these drugs can cause serious complications such as gastro-intestinal bleeding. It's estimated that 1,900 patients die in Canada every year due to these drugs.

This is a high price to pay for pain relief --and I have no desire to lose a tennis partner. That's why I told my friend not to take this chance and to use muscle-strengthening exercises and the new locally applied Pennsaid.

Pennsaid is a non-steroidal anti-inflammatory solution initially applied to the surface of the knee four times a day. Since it's locally applied, the likelihood of serious side-effects is decreased markedly. Equally important, studies show that it is as effective in controlling symptoms of osteoarthritis as the oral NSAIDs.

The most common side-effect of Pennsaid is a skin rash. But this problem pales in comparison to losing your life or possibly developing kidney and liver problems with the oral NSAIDs.

Doctors and patients have been waiting a long time for a safer product to treat osteo-arthritis. Pennsaid, a prescription drug, fills that need and is a godsend for arthritic patients.