bavi India trials...My opinions...
To date, we have seen that bavi is safe. Several years ago I believe that most scientists would have agreed that targeting your own body's tissue (PS) with immunostimulatory antibodies would be a recipe for autoimmune induction. Most scientists today likely feel the same way. Only in the last few months has there been a substantial growing ripple in the scientific community suggesting that PS is immunosupressant, and that targeting it may be a way of treating disease. Peregrine has exclusive licencing rights over this target, and treating disease in this fashion. We are the only company that I am aware of that has an anti-PS antibody in clinical trials. As I said earlier, there is an ever growing body of evidence that bavi is safe. As bavi is the first antibody to target PS, it has a lot to prove...we're not following an already proven target...everything about bavi is completely new.
In the first India phase 1 trial, bavi was used in combination against several metastatic, chemo resistant solid tumors. In that trial, the two women with breast cancer had COMPLETE TUMOR RESPONSES, meaning their primary breast cancer lesions completely disappeared...in 8 weeks. Now there is lots of stuff we don't know about these two women, for example what type of breast cancer they had (ductal vs lobular, progestine +/-, Estrogen +/-, sites/degree of metastasis) or whether there was new metastasis, or if bavi prevented its occurrence. What matters is that there is a phase 2 breast cancer trial currently ongoing, with the first 15 patients already enrolled, and data potentially available in less than 8 weeks. This will be the first real glimpse at bavi's potential efficacy against cancer, specifically the most common cancer in women. This is the sort of data we need to drive partnering discussions that can see bavi begin to attain serious value. If bavi shows real potential, then you can bet large pharmaceutical companies will be lining up to get a piece. Right now, bavi remains largely unproven...and I don't think that anyone is willing to step to the plate and pay what management is asking. If bavi fails to show strong efficacy then i doubt anyone will...but my opinion is that we are going to see something quite remarkable, and we will see a real partnership very close afterwards. As to the other India phase 2 trials...I do not see them as the immediate value driver. I do not know what is with the delay more than anyone else on the board. Anything on this board is only speculation, and there are many hurdles yet for bavi to clear.
Peregrine has been around for a long time...and I have only been here 2.5 years, but they have never been so close to something potentially so big. Bavi = the rights to treating disease in a totally new fashion. Its not just one type of cancer, or one virus.
Bavi and Peregrine are still a long shot, but I believe in the science, and I do not think that management's intentions are sinister. I think they have done what they have had to do, however painful, to get bavi to where it is and to protect the platform. I couldn't bare to sell my shares, becuase if nothing else, bavi always gives me something to be excited about...Good luck longs.
P.S. two more weeks and I'm officially a pharmacist!! so close...PPHM, bring me a grad gift, lol.
AI
