Pharmacopeia Drug Discovery, Inc. (PCOP)

[surf1944]

Pharmacopeia Announces Upcoming Late-Breaker Presentation of Phase 2a Results for Its First-in-Class Investigational DARA Compound, PS433540
Tuesday April 15, 7:30 am ET

PRINCETON, N.J., April 15 /PRNewswire-FirstCall/ -- Pharmacopeia (Nasdaq: PCOP - News), an innovator in the discovery and development of novel small molecule therapeutics, announced today that results from the company's Phase 2a clinical trial evaluating PS433540, its first-in-class Dual Acting Receptor Antagonist (DARA), will be presented as a late-breaking clinical trial at the American Society of Hypertension (ASH) Twenty-Third Annual Scientific Meeting and Exposition in New Orleans, May 14-17, 2008.

PS433540 is being developed as a potential treatment for both hypertension and diabetic nephropathy and is the first and only blood pressure product candidate in development that possesses two validated mechanisms of action in a single compound.

Joel Neutel, MD, lead investigator and Director of Research, Orange County Research Center, Tustin, Calif., will present results of the Phase 2a clinical trial. In addition to the late-breaker, Pharmacopeia will also present data from its Phase 1 Multiple Ascending Dose (MAD) Study of PS433540.

Late-breaker presentation:
-- "A Double Blind, Placebo Controlled Study to Evaluate the Safety and
Efficacy of a Novel New Dual Acting Receptor Antagonist (DARA
Compound) in Human Subjects with Hypertension"
-- Friday, May 16, 2008, 5:38 - 5:55 p.m. CDT (6:38 - 6:55 p.m. EDT)
-- New Orleans Marriott, Acadia Ballroom, 3rd Floor


Poster presentation:
-- "PS433540 a Novel Dual Acting Receptor Antagonist Dose Dependently
Increases Plasma Renin Activity in Healthy Volunteers"
-- Abstract # P-14
-- Wednesday, May 14, 2008, Posters on Display: 3:00 - 7:00 p.m. CDT
(4:00 - 8:00 p.m. EDT), Poster Discussion: 5:15 - 6:15 p.m. CDT
(6:15 - 7:15 p.m. EDT)
-- New Orleans Marriott, Le Galerie Ballroom, 2nd Floor