Keep in mind that while the chemiluminescent high thruput equipment is a cool new toy for Abbott, it also has its shortfalls. I listed a few of the problems associated with chemiluminescent assays and equipment. I am not interested in the problems, only to make a point that our technology works. Maybe there is some difficulty as to why it won't function at warp speed on the speedy analyzer but I personally don't care if the lab takes an extra hour or day to process my test if it will come back at an exceptionally accurate .954
Abbott can analyze a psa test in minutes or a CEA in minutes or any of their other Bullshit tests that are 40% accurate. I am looking forward to an accurate test that works at 96% even if it takes an extra day to get back.
MANUFACTURER: Abbott Diagnostics, Division of Abbott Laboratories, Abbott Park, Illinois.
PRODUCT: ARCHITECT LH Reagent Kit; a chemiluminescent microparticle immunoassay for quantitative determination of human leutenizing hormone in human serum and plasma for the prediction of ovulation, in the evaluation of infertility, and diagnosis of pituitary and gonadal disorders. Recall #Z-026-0.
REASON: Results generated with these lots may exhibit an over recovery.
-----------------------------------------------------------------------------------------------------------------------------------
PRODUCT: Architect Free T3 Reagent Kit, a Chemiluminescent Microparticle Immunoassay (CMIA) for the quantitative determination of free triiodothyronine (Free T3) in human serum and plasma. Recall #Z-1212-9.
REASON: Low recovery when used with multi-constituent controls.
-----------------------------------------------------------------------------------------------------------------------------
The low specificity of a chemiluminescent. assay is. another problem.
----------------------------------------------------------------------------------------------------------
The difficulties faced in connection with the incompatibility of the peroxyoxalate reaction with protic media, on account of insufficient resistance to solvolysis and low solubility, have been overcome by the use of a new solvent system, preferably consisting of about 50 percent water.
----------------------------------------------------------------------------------------------------------------
but difficulties in obtaining quenching data make the modeling efforts somewhat less successful than that for OH* chemiluminescence.
-------------------------------------------------------------------------------------------------------
The main problem for an embodiment having a glass bottle and a chemiluminescent light source resides in difficulties for activating the light source by pressure when it is placed upon a rigid outer wall, or in a rigid reservoir.
-------------------------------------------------------------------------------------------------------------
Such procedures have difficulties associated with contaminants
picked up during the purification procedure and the possible loss of signal from unstable
NO species of interest.
Our chemiluminescence method, bypasses all of these difficulties by directly
determining heme-NO levels as low as 10 nM, even in hemolysate without any sample
purification, and without interference of other NO species.
---------------------------------------------------------------------------------------------------------------------
has its own difficulties with analysis. The onlychange made to the analysis was the actual sampleused. It was changed as necessary due to stability ofthe sulfur compounds in the mixture.Some problems concerning investigation of liquid-phase chemiluminescence
----------------------------------------------------------------------------------------------------------------------
More expensive, potential background problems due to high sensitivity and the kit
-----------------------------------------------------------------------------------------------------
The twin problems of timing and reagent instability also plague other chemiluminescence chemistries that have been developed to detect target analytes
-------------------------------------------------------------------------------------------------------------------
PROBLEMS Chemiluminescence Chemiluminescence, described later in this chapter, ... sample can also increase the incidence of chemiluminescent interferences
----------------------------------------------------------------------------------------------------------------
chemiluminescent problems during the counting process, resulting in low counting efficiency (40-60%).
--------------------------------------------------------------------------------------------------------------
AI
