GTC Biotherapeutics (fka GTCB)

[jessellivermore]

Are there proteins yeast can not produce ???

The answer is there are proteins yeast can not produce in high enough yields to compete with GTC's platform. Glycolisation is only half the battle. In antibody dependent (cell mediated) immune reponse ADCC. The antibody has two ends. The active end attaches to the target cell surface antigen...the other end....the glycolised end attracts Natural Killer Cells which then destroy the target cell. The glycolization pattern effects the affinity of the NKCs for the antibody.

Many proteins are hard to express in bacterial, yeast or even mamalian cell culture due to the complex 3-dimensional folding patterns necessary for them to function. This is true of plasma proteins as a class.....and is of course an important target for GTC's platform which has little competition at present