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Friday, March 07, 2008 3:52:13 PM
not so long ago this was the general sentiment - today we know the lock and key analogy is an oversimplification. there are multiple locks and keys, and often multiple modifiers (coactivaros/suppressors) that can act on a partiuclar lock and/or key, so that the net effect is a (often tissue-specific) unique response to a particular drug/hormone. the science is more fleshed out for estrogen than progesterone, so i suggest you read a good review (sorry don't have a reference handy) on SERMs to get an idea for the complexity of the system. note that the endometrium is comprised of not just one tissue type, but rather several distinct elements - glands, stroma, vasculature - so the effects on the endometrium may be distinct and unique depending on the profile of the drug
Recent RPRX News
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- Ascendis Pharma and Royalty Pharma Enter into $150 Million Royalty Funding Agreement • GlobeNewswire Inc. • 09/03/2024 09:06:29 PM
- Royalty Pharma to Present at Morgan Stanley’s 22nd Annual Global Healthcare Conference • GlobeNewswire Inc. • 08/28/2024 08:15:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/12/2024 11:20:32 PM
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- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/12/2024 11:17:16 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/08/2024 01:02:22 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/08/2024 11:20:53 AM
- Royalty Pharma Reports Second Quarter 2024 Results • GlobeNewswire Inc. • 08/08/2024 11:00:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/07/2024 11:04:01 AM
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- Form 8-K - Current report • Edgar (US Regulatory) • 06/20/2024 12:03:31 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/10/2024 08:58:32 PM
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- Form 424B5 - Prospectus [Rule 424(b)(5)] • Edgar (US Regulatory) • 06/03/2024 01:13:40 PM
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