5. The interim is scheduled at an appropriate later point than half time so that the nominal alpha is reasonable.
For example, I'll take a small wager that that's why Dr. Gold is optimistic about the IMPACT interim look rather than because some alpha allocation function other than O'Brien-Fleming was used. There is a lot of room between 180 and 360 to play with. And, Dendreon surely do not want Tom to feel slighted and write another letter after the interim .
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