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Monday, January 28, 2008 9:46:55 AM
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[0169] The methods and uses of the present invention are particularly intended for use in animals and patients that have, or are at risk for developing, any form of vascularized tumor; macular degeneration, including age-related macular degeneration; arthritis, including rheumatoid arthritis; atherosclerosis and atherosclerotic plaques; diabetic retinopathy and other retinopathies; thyroid hyperplasias, including Grave's disease; hemangioma; neovascular glaucoma; and psoriasis.
[0685] The in vivo imaging compositions and methods of the invention can be used in imaging per se, or in pre-imaging a site in the body to form a reliable image prior to treatment. Preferably, the imaging is tumor imaging. These compositions and methods can also be applied to imaging and diagnosis of other diseases or conditions associated with aminophospholipids and anionic phospholipids, such those involving cell activation and/or apoptosis, including angiogenic diseases, atherosclerosis, viral infections, and other such conditions in which an internal image is desired for diagnostic or prognostic purposes or to design treatment.
[0806] Whether based upon anti-angiogenesis, prothrombotic vasculature or other anti-vascular mechanisms, the present invention may thus be used to treat prevalent and/or clinically important diseases outside the field of cancer, including arthritis, rheumatoid arthritis, psoriasis, atherosclerosis, diabetic retinopathy, age-related macular degeneration, Grave's disease, vascular restenosis, including restenosis following angioplasty, arteriovenous malformations (AVM), meningioma, hemangioma and neovascular glaucoma. Other targets for intervention include angiofibroma, atherosclerotic plaques, corneal graft neovascularization, hemophilic joints, hypertrophic scars, osler-weber syndrome, pyogenic granuloma retrolental fibroplasia, scleroderma, trachoma, vascular adhesions, synovitis, dermatitis, various other inflammatory diseases and disorders, and even endometriosis. Further diseases and disorders that are treatable by the invention, and the unifying basis of such disorders, are set forth below.
etc.
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and a few Pisetsky of Duke, then Haynes & Pisetsky -
Pisetsky of Duke 2005 -
![](http://www.fotothing.com/photos/us/4096.jpg)
Pisetsky of Duke 2006 -
![](http://www.fotothing.com/photos/us/4097.jpg)
Haynes and Pisetsky 2007 -
![](http://www.fotothing.com/photos/us/4099.jpg)
![](http://www.fotothing.com/photos/us/4103.jpg)
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It seems to me like Haynes wants to clean up the microparticles to see if it will facilitate a more robust immune response.
Will he be successful?????????????????????
![](http://img405.imageshack.us/img405/7053/thekickeruj3.jpg)
j
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