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Post# of 253566
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biophud

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biophud

Re: dewophile post# 57772

Sunday, 01/20/2008 1:08:29 PM

Sunday, January 20, 2008 1:08:29 PM

Post# of 253566
Goof reference on antagonism of BLYS and APRIL. It looks like it is unclear/unknown if some of these agents inhibit BLYS/APRIL heterodimers. At this point, I'm not sure what is the ideal inhibition strategy. While inhibition of both BLYS and APRIL may seem more potent, there is data that there is an inverse association between circulating APRIL levels and serological and clinical disease activity in patients with systemic lupus erythematosus (see reference below).

http://www.ncbi.nlm.nih.gov/pubmed/15308519?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Comments appreciated,
biophud
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