Javelin Pharmaceuticals Inc (JAV)

[Bio_pete]

We were aware of Acetavance (Acetaminophen IV) since this was mentioned by an analyst during one of JAV's presentations. You have to give large doses 1000mg and its still a weak pain reliever. Acetaminophen at doses greater than or equal to 2000 mg/day may also be associated with a significantly increased risk for upper-GI complications.

The problem with pain studies is that its subjective and individuals have varying pain sensitivity. Older patients need less narcotics, pts taking meds at home or use alcohol frequently have a tolerance, red heads need more meds, surgical technique or anatomical differences all play a role in how much pain people experience during the procedure & post-procedure.

The only competition at this point is Toradol in the US. If Dyloject can get approved in the US for post-operative pain before Acetavance then it will become the standard. If Acetavance is approved first for this indication then it would slow down Dylojects sales.

Diclofenac is an effective analgesic. Studies show that a single 50 mg dose can cut pain scores in half over a 4-6 hour period compared to placebo.