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Post# of 252676
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Re: iwfal post# 56580

Friday, 12/21/2007 7:44:25 PM

Friday, December 21, 2007 7:44:25 PM

Post# of 252676
"One measure of this is what is the p value for the non-responders vs control. If it is stat sig the wrong way then both subgroups are probably worthless."

A caller asked the company if the presented results implied that the non-responder group did worse than the control arm. The company replied "yes".

Was this a mistake? Did he mean "it trended worse" (as opposed to stat sig worse)? This would seam like a very sloppy reply by somebody like me, and absurdly sloppy for a biotech exec on a CC.

If not a mistake, it makes it quite likley that a least some portion of the treatment effect amongst responders is mearly a "detection of the healthy" effect.

There are definitely some bad numbers in the closet from the way the call disclosed almost nothing. I would not be surprised if this is it.
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