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Re: None

Thursday, 12/20/2007 6:13:44 PM

Thursday, December 20, 2007 6:13:44 PM

Post# of 12660
Clark – Not trying to be a wise ass, but

You wrote on the BV board earlier today the following:

“If you give me a trial size, a number of events and the resulting HR I will tell you the p value with fairly tight tollerances.”

http://investorshub.advfn.com/boards/read_msg.asp?message_id=25460115

How about two trials: 1) with 180 events and a sensitivity analysis with HRs ranging from 1.1 to 1.5 (maybe in .05 increments), what would the resulting log p-values be? 2) with 360 events and a sensitivity analysis with HRs ranging from 1.1 to 1.5 (maybe also in .05 increments), what would the resulting log rank p-values be? I guess such an analysis would not take into account the shape of the survivor curves, so just assume these are the overall HRs for the trials.

Just hypothetical, of course. I have no specific trial in mind ;)

I assume this would not be a great deal of work for you, as I suspect that you have some stats model set up and it would just be just plugging in the variables.

Thanks for you thoughts and have a Very Happy Holidays.

Steve

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