How about two trials: 1) with 180 events and a sensitivity analysis with HRs ranging from 1.1 to 1.5 (maybe in .05 increments), what would the resulting log p-values be? 2) with 360 events and a sensitivity analysis with HRs ranging from 1.1 to 1.5 (maybe also in .05 increments), what would the resulting log rank p-values be? I guess such an analysis would not take into account the shape of the survivor curves, so just assume these are the overall HRs for the trials.
Just hypothetical, of course. I have no specific trial in mind ;)
I assume this would not be a great deal of work for you, as I suspect that you have some stats model set up and it would just be just plugging in the variables.
Thanks for you thoughts and have a Very Happy Holidays.
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