<With a given number of events at the interim and an allocated p value, is the Hazard Ratio determined automatically or does the shape of the curve or some other factor(s) make it a variable independent of events and p value?>
I am not the person to answer this, but I think the answer is both. It can be both instantaneous at all points along the curve, and overall at the end. The instantaneous HRs along the curve builds to overall HR. What worries me about the interim is the potential low HRs for patients enrolled less than 24 mos. (over 40% of the pop. at 4Q08 ) squeezing the hell out of the overall HR and p-value to that point.
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