DNAprint Genomics (DNAG)

[worktoplay]

I liked this paragraph as well:

There has been increased interest in association studies as a useful approach to map common disease and drug response genes (Risch and Merikangas, Science 273: 1516-1517, 1996; Jorde, Genome Res. 10: [1435-1444,] 2000; Nordborg and Tavare, Trends Genet.

18: 83-90,2002). Until the present disclosure, however, the implication of ancestry for identifying these genes has not been fully appreciated. As such, the methods of the invention provide a previously undescribed platform for the identification of genes associated with disease susceptibility and drug responsiveness, as well as for the development of advanced forensic methods. As such, compositions and methods are provided for inferring an individual's response to commonly used medications, which, remarkably, is a function of individual ancestry; the disclosed markers and methods are, to a differing extent for each drug, useful for the inference of such response. In addition, compositions and methods are provided for inferring individual and/or group ancestral proportions from knowledge of the individual's or group's DNA sequences. Further, compositions and methods are provided for using knowledge of ancestry relevant DNA sequences to identify disease susceptibility and drug response genes through the MALD process. Also, compositions and methods are provided for qualifying and normalizing study groups for more traditional methods of mapping disease genes. Each of these processes requires an accurate knowledge of ancestry, which can be determined using the methods and compositions disclosed herein.

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