INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
(11) WO 03/045227
REVISED VERSION
(13) A3
(21) PCT/US02/38345
(22) 26 November 2002 (26.11.2002)
(25) English
(26) English
(30) 60/334,310 28 November 2001
(28.11.2001) US
(30) 60/410,363 11 September 2002
(11.09.2002) US
(43) 05 June 2003 (05.06.2003)
(51)7 C12Q 1/68, C12P 19/34, C12M 1/34, C07H 21/04
(54) SINGLE NUCLEOTIDE POLYMORPHISMS AND COMBINATIONS THEREOF PREDICTIVE FOR PACLITAXEL RESPONSIVENESS
(71) DNAPRINT GENOMICS, INC. [US/US]; 900 Cocoanut Avenue, Sarasota, FL 34236 (US).
(72)
(75) FRUDAKIS, Tony, N. [US/US]; 3707 Plumosa Terrace, Bradenton, FL 34210 (US).
(74) HAILE, Lisa, A.; Gary Cary Ware & Friedenrich LLP, Suite 1100, 4365 Executive Drive, San Diego, CA 92121-2133 (US).
(81) AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
(84) ARIPO patent (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian patent (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European patent (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, SK, TR), OAPI patent (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
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Published
-- with international search report
-- before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments
(88) 21 August 2003 (21.08.2003)
(57) Single nucleotide polymorphisms (SNPs) and combinations of SNPs that allow an inference as to whether a cancer patient is likely to respond or not respond to paclitaxel (Taxol®) are provided. Also provided are methods of determining a whether a cancer patient should be treated with paclitaxel.
