InvestorsHub Logo
Followers 2
Posts 283
Boards Moderated 0
Alias Born 08/25/2006

Re: iwfal post# 5125

Tuesday, 11/27/2007 2:40:50 AM

Tuesday, November 27, 2007 2:40:50 AM

Post# of 12660
But isn't the "ratio of normalized events in each arm" what plots the curves? I think I understand the "no events, no improvement in p-value" since over that period with no deaths in both arms you would have two parallel horizontal lines. BTW, Clark have you had a chance to run the simulation models you mentioned in message #4145 - possibly low HR to about 24 to 30 months and good separation thereafter - enrollment ramp as Wall has suggested - overall HR of 1.25 to 1.45 with sensitivities - interim (at 180 deaths) and final analysis p-values based on these assumptions. I wish so much that we could post excel models here to play around with. I have no stats background and had other things on my 19 year old mind when I took stats in college. Your contributions are always appreciated.

Thanks

Steve

Join the InvestorsHub Community

Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.