Avid Bioservices Inc (CDMO)

[jazzbeerman]

Upstream Interference of TGF-beta:

what was that again?


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* "interference with immunosuppressive mechanisms could be attempted upstream"

* "interfering with the pathway utilized by tumor cells to promote MSC in vivo generation"

* "As we reported that exosomes released by melanoma cells are likely responsible for the induction of CD14+HLA-DR–/lo cells secreting TGF-ß"

* "thwarting the process of exosome production could represent a tool for interrupting the immunosuppressive circuits established by tumor cells and for retrieval of cancer immunity"

http://jco.ascopubs.org/cgi/content/full/25/29/4696


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Evolution has favored pathogenesis that resembles apoptosis,


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