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Tuesday, October 30, 2007 11:29:38 AM
* In the SINGLE DOSE study, (in former non responders to immunotherapy), half the patients in the 1 mg/kg cohort, and also half the patients in the 3 mg/kg cohort, achieved a half log decrease.
![](http://img410.imageshack.us/img410/5599/logs6mgij2.jpg)
and that was just one single dose of bavi, in former non responders to immunotherapy...
* There was also a patient who got 3 mg and did a 1.5 log decrease.
and again- that was just one single dose of bavi, in former non responders to immunotherapy...
* then, 5 out of 6 patients at the 6 mg dose did a half log, or better
![](http://img61.imageshack.us/my.php?image=logs2fb9.jpg)
and again- that was just one single dose of bavi, in former non responders to immunotherapy...
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In the multi-dose study, (and it was only four doses over 2 weeks), half the patients at 3 mg did 1 log.
Maybe less bavi, more doses, over a longer period, will achieve good viral reduction.
PPHM seems to think that once a week for a longer time period is promising.
and I can only assume that they feel this way based on Duke research INTO THE IMMUNE MODULATING MOA.
![](http://img211.imageshack.us/img211/3277/moapy2.jpg)
Maybe a 0.3 mg/kg dose will have impressive results after 8 weekly infusions.
Maybe the optimal dose will still be around 3.0
j
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