Avid Bioservices Inc (CDMO)

[jazzbeerman]

serene,

'government has interest in viral bavituximab, thus its monetary potential is not so barren as all that.'


I think that qualifies as the understatement of the week :)


So far the DoD has funded:

bavi against prostate cancer,
bavi against breast cancer,
and bavi as a tumor imaging agent.

I expect the DoD (via DTRA's TMTI program) to fund bavi against HFV's, with the largest grant yet.


When Duke's / CHAVI's / Gates CAVD's Barton Haynes' research into how exposed PS is the reason that the immune system fails early against HIV,

- and that poster info (from the recent Gates HIV vaccine conf.) is first out of over two hundred posters, but has yet to show up in any of Haynes published papers,

-and Haynes' other poster from the conf., (listed fifth) has already been published as a paper recently, (which also had to do with phospholipid binding of nabs),

I'd expect him to publish a paper on their work into exposed PS from apoptotic cells and the microparticles shed from those cells as the critically important link responsible for the success of the virus during acute HIV infection.

They're already on record several times mentioning this topic -

from January in the CHAVI admin meeting,
from March on Haynes CAVD Mision and Goals page,
from April's CHAVI 012 clinical study,
and now from Sept at the Gates Seattle event.



There is a growing consensus in the research community that shed membrane micro-particles play a much larger immunosuppressive role than previously thought in both cancer and HIV pathogenesis, and it's looking like an important mechanism of action of Bavituximab is in binding those PS-exposing micro-particles, thus clearing out the literally overwhelming apoptotic debris that has been down-regulating the immune response to HIV and cancer.


j