Avid Bioservices Inc (CDMO)

[jazzbeerman]

bavi antibacterial -

"MRSA is a bacteria, not a virus."


Bacteria wear exposed PA, an anionic phospholipid.

Bavi binds PA.


Thorpe/Ran:

[0820] Most bacteria express the anionic phospholipid, PA. Antibodies that bind to PA, optionally with binding to other anionic phospholipids, can therefore be used as anti-bacterial agents. Although the antibodies of the invention can be prepared in E. Coli, and are thus not bacteriocidal in all circumstances, an anti-bacterial role in vivo is believed to result from the ability to fix complement. An intact antibody rather than an antibody fragment should therefore be used as an anti-bacterial agent. The 3G4 (ATCC 4545) and like antibodies are preferred for use in such embodiments, although any antibody that fixes complement and binds to PA may be employed, such as other PA-binding antibodies from Table 4.

http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=%2Fnetahtml%2FPTO%2Fsearch-adv.html&r=5&p=1&f=G&l=50&d=PG01&S1=%28%22thorpe+philip%22.IN.%29&OS=in/%22thorpe+philip%22&RS=IN/%22thorpe+philip%22


-------



j