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Re: rancherho post# 4722

Friday, 08/24/2007 5:17:04 PM

Friday, August 24, 2007 5:17:04 PM

Post# of 12660
Nature Reviews Cancer reported this month on another factor that possibly mediates prostate cancer metastasizing to Bone:

Prostate cancer

A secreted isoform of ERBB3 promotes osteonectin expression in bone and enhances the invasiveness of prostate cancer cells
Chen, N. et al. Cancer Res. 67, 6544–6548 (2007)

Article
Prostate cancer preferentially metastasizes to bone. Previously, a secreted isoform of ERBB3 (p45-sERBB3) was detected in metastatic prostate cancer cells isolated from patients and was shown to interact with osteoblasts. Chen et al. now show that p45-sERBB3 stimulates mouse bone to secrete factors including osteonectin, which increases the invasiveness of prostate cancer cells in vitro. Invasion induced by p45-sERBB3 was also blocked by osteonectin antibodies. Thus, p45-sERBB3 and osteonectin might mediate the interactions between metastasizing prostate cancer cells and bone.
http://www.nature.com/nrc/journal/v7/n9/full/nrc2225.html#Prostate-cancer
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