~*~ Jerusalem ~*~

[genisi]

"ever heard of Cytogenix?"

Nope. After a glimpse at their web I can only tell you that Antisense technology is no longer considered "sexy". It works differently than RNA interference (RNAi). Antisense needs to bind the RNA and rely on the activity of RNase that recognize dsRNA. So it acts by killing the messenger. RNAi is much more common and can kill the messenger or can kill translation and is sequence specific and relies on a cleaving enzyme that trims it to a 20-13 nucleotide long. Antisense had a problem of stability and delivery. RNAi is stable and the delivery is about to be resolved. Lots of Antisense scientists I know have shifted to the RNAi arena and that is also where the money goes.

Idit

p.s. I could not answer yesterday as my daily posts reached the max amount.