DNAprint Genomics (DNAG)

[mingwan0]

Another possible connection

Grant Number: 5K07CA091849-03
PI Name: BARNHOLTZ-SLOAN, JILL S.
PI Email: [e-mail]
PI Title: ASSISTANT PROFESSOR
Project Title: Analysis of Ethnic Admixture in Lung Cancer

Abstract: DESCRIPTION (provided by applicant): This proposal describes a five-year plan developed for a Cancer Prevention, Control, Behavioral and Population Sciences Career Development Award. It outlines a program that integrates education, teaching and research to develop my skills in statistical genetics, molecular biology, cancer biology, human genetics and genetic epidemiology. My research plan consists of two projects: (l) higher level genetic modeling of early onset lung cancer cases and controls with admixture versus ethnicity as a covariate and (2) application of an admixture, population substructure and disequilibria testing procedure to early onset lung cancer cases, population-based controls and nuclear families. Project l uses data from a funded study on early onset lung cancer of African-Americans and Caucasians. Nine candidate loci believed to be involved in lung cancer risk along with 35 population specific markers (PSAs) for Africans and Europeans combined, are being typed for each case and a matched population and familial control. An admixture algorithm will be written, programmed and tested on cases, controls and parents to estimate individual and population admixture, using the PSAs. Logistic regression models and decision tree models (classification and regression tree) will be compared when modeling the genotypes of the candidate loci and other collected environmental/descriptive variables, in order to assess the difference between using an ethnicity variable versus an individual admixture estimate variable. Project 2 will build on the already developed admixture estimation algorithm (Project l). I will develop a complete procedure that will estimate individual and population admixture and within population substructure and will test for induced linkage disequilibrium (LD) and Hardy-Weinberg disequilibrium (HWD), for all cases, controls and nuclear families. This procedure will be tested in a computer-based simulation, using the early onset lung cancer data as a model, in order to estimate the statistical power and test characteristics such as false-positive and false-negative rates. Linkage disequilibrium mapping will also be performed on the study data. Both of these projects will address epidemiological study design issues about ethnicity and using population-based versus familial based controls. From the studies proposed, a recommendation could be made on how to utilize individual admixture information in the choice of controls for epidemiological studies. These projects will give me experience in developing methodology in statistical genetics and genetic epidemiology, while also helping me to better understand etiology of disease.

Thesaurus Terms:
African American, caucasian American, lung neoplasm, neoplasm /cancer epidemiology
disease /disorder onset, gene environment interaction, gene interaction, genetic model, genetic susceptibility, model design /development, neoplasm /cancer genetics
clinical research, human subject

Institution: WAYNE STATE UNIVERSITY 656 W. KIRBY DETROIT, MI 48202
Fiscal Year: 2003
Department: INTERNAL MEDICINE
Project Start: 25-SEP-2001
Project End: 31-AUG-2006
ICD: NATIONAL CANCER INSTITUTE
IRG: NCI

http://www.parkwayalumni.org/class80.html

Jill Barnholtz-Sloan, North '89, received a Ph.D. in Biostatistics and Statistical Genetics from Univ. of Texas School of Public Health and MD Anderson Cancer Center in May 2000. She is currently an assistant professor of internal medicine and oncology at Wayne State Univ. School of Medicine and Karmanos Cancer Institute in Detroit.

Add in this:

Barnholtz-Sloan JS, Sloan AE, Schwartz AG. Racial differences in survival after diagnosis with primary malignant brain tumor. Cancer. 2003 Aug 1; 98(3): 603-9.

Barnholtz-Sloan JS, de Andrade M, Dyer TD, Chakraborty R. Admixture effects in the traditional linkage analysis of admixed families. Ethn Dis. 2002 Summer; 12(3): 411-9.

Barnholtz-Sloan JS, Tainsky MA, Abrams J, Severson RK, Qureshi F, Jacques SM, Levin N, Schwartz AG. Ethnic differences in survival among women with ovarian carcinoma. Cancer. 2002 Mar 15; 94(6): 1886-93.

Barnholtz-Sloan JS, de Andrade M, Chakraborty R. The impact of population admixture on traditional linkage analysis. Ethn Dis. 2001 Autumn; 11(3): 519-31.

Now it's getting interesting...

Coincidentally Mark Shriver has an association with Wayne and an interest in lung cancer.

BTW, the NIH project details are from the CRISP database:

http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen