My odds are as follows: OS is focus of questioning and discussion: 1/2 Let's wait for data: 60% Not wait: 40% Not focus: 1/2 PFS compelling: 75% PFS not compelling: 25% This gives case odds of: 1a 30% 1b 20% 2a 37.5% 2b 12.5% Odds of approval are: 1a 20% 1b 70% 2a 80% 2b 5% Overall odds: 51% (did not game this either) Jon