Zimulti panel was concerned about depression related to suicidal thoughts. Cannaboids create the feeling of Euphoria and the "munchies". A drug to inhibit the munchies might also lead to depression and suicide. I don't think that is an enormous leap to make when you are considering the approval of a drug that in a clinical trial has this side effect. If Vioxx taught the anybody anything it is that safety will be a major concern in the minds of people reviewing the risk benefit of a drug.