Exten Industries (fka BB: EXTI)

[Patricia_1]

Correction to Patent numbers to research

5,043,260
4,795,459
5,795,711
6,136,525
6,107,043
6,017,760
5,869,243
6,129,911

United States Patent 5,043,260
Jauregui August 27, 1991

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Perfusion device with hepatocytes


Abstract
A perfusion device to grow and maintain hepatocytes including a chamber having a perfusion inlet and a perfusion outlet, a semipermeable membrane in the chamber defining separate perfusion and hepatocyte compartments, and hepatocytes in the hepatocyte compartment attached via oligosaccharide-lectin recognition linkage to a biopolymer support in the hepatocyte compartment.

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Inventors: Jauregui; Hugo O. (Providence, RI)
Assignee: Rhode Island Hospital (Providence, RI)
Appl. No.: 116525
Filed: November 2, 1987

http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/neta....



United States Patent 4,795,459
Jauregui January 3, 1989

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Implantable prosthetic device with lectin linked endothelial cells


Abstract
An implantable prosthetic device made of biocompatible polymer and having a substantially continuous layer of autologus living cells attached via oligosaccharidelectin recognition linkages.


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Inventors: Jauregui; Hugo O. (Providence, RI)
Assignee: Rhode Island Hospital (Providence, RI)
Appl. No.: 051500
Filed: May 18, 1987


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United States Patent 5,795,711
Mullon , et al. August 18, 1998

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Cryopreserved hepatocytes and high viability and metabolic activity


Abstract
An artificial liver support system is described herein which comprises cryopreserved hepatocytes having an initial viability of 80-99% and a metabolic activity 50-80% of fresh hepatocytes. Further disclosed are hepatocytes cryopreserved by dispensing hepatocytes into freezing containers, freezing the containers from between minus 50 to minus 90 degrees Celsius, storing the containers in liquid or vapor nitrogen, thawing the cryopreserved hepatocytes when ready for use and removing residual cryoprotectant media.


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Inventors: Mullon; Claudy Jean-Paul (Framingham, MA); Cain; Shawn Paul (N. Chelmsford, MA); Perlman; Timothy Jon (Lexington, MA); Jauregui; Hugo O. (Providence, RI); Naik; Sharda (Cranston, RI); Santangini; Henry A. (Cranston, RI); Trenkler; Donna M. (Greene, RI)
Assignee: Circe Biomedical, Inc. (Lexington, MA)
Appl. No.: 627446
Filed: April 4, 1996


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United States Patent 6,136,525
Mullon , et al. October 24, 2000

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Method of cryopreserving hepatocytes


Abstract
An artificial liver support system is described herein which comprises cryopreserved hepatocytes having an initial viability of 80-99%. Further disclosed are hepatocytes cryopreserved by dispensing hepatocytes into freezing containers, freezing the containers from between minus 50 to minus 90 degrees Celsius, storing the containers in liquid or vapor nitrogen, thawing the cryopreserved hepatocytes when ready for use and removing residual cryoprotectant media.


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Inventors: Mullon; Claudy Jean-Paul (Framingham, MA); Cain; Shawn Paul (N. Chelmsford, MA); Perlman; Timothy Jon (Lexington, MA); Jauregui; Hugo O. (Providence, RI); Naik; Sharda (Cranston, RI); Santangini; Henry A. (Cranston, RI); Trenkler; Donna M. (Greene, RI)
Assignee: Circe Biomedical, Inc. (Lexington, MA)
Appl. No.: 364893
Filed: August 2, 1999


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United States Patent 6,107,043
Jauregui , et al. August 22, 2000

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Immortalized hepatocytes


Abstract
The invention features a virally-immortalized mammalian hepatocyte, which is derived from a normal liver cell, has differentiated hepatocyte-specific metabolic activity, has the ability to proliferate, and is nontumorigenic after prolonged culture.


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Inventors: Jauregui; Hugo O. (Providence, RI); Liu; Jin (Barrington, RI)
Assignee: Rhode Island Hospital (Providence, RI)
Appl. No.: 246968
Filed: February 9, 1999


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United States Patent 6,017,760
Jauregui , et al. January 25, 2000

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Isolation and culture of porcine hepatocytes


Abstract
A perfusion device such as a liver assist device containing a housing defining a perfusion inlet and a perfusion outlet, a porous membrane structure mounted within said housing to define a perfusion compartment and an adjacent hepatocyte compartment, and porcine hepatocytes isolated from a porcine liver by retrograde perfusion.


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Inventors: Jauregui; Hugo O. (Providence, RI); Naik; Sharda (Cranston, RI); Santangini; Henry (Cranston, RI); Trenkler; Donna M. (Greene, RI)
Assignee: Rhode Island Hospital (Providence, RI)
Appl. No.: 541462
Filed: October 10, 1995


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United States Patent 5,869,243
Jauregui , et al. February 9, 1999

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Immortalized hepatocytes


Abstract
The invention features a virally-immortalized mammalian hepatocyte, which is derived from a normal liver cell, has differentiated hepatocyte-specific metabolic activity, has the ability to proliferate, and is nontumorigenic after prolonged culture.


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Inventors: Jauregui; Hugo O. (Providence, RI); Liu; Jin (Barrington, RI)
Assignee: Rhode Island Hospital (Providence, RI)
Appl. No.: 611171
Filed: March 5, 1996


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United States Patent 6,129,911
Faris October 10, 2000

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Liver stem cell


Abstract
The invention provides a primary liver stem cell and a cell
doublet consisting of a hepatocyte and the stem cell, both of which are derived from normal liver tissue. Methods of isolating the cells, genetically altering the cells, and using the cells for transplantation are also within the invention.


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Inventors: Faris; Ronald A. (Providence, RI)
Assignee: Rhode Island Hospital, A LifeSpan Partner (Providence, RI)
Appl. No.: 113774
Filed: July 10, 1998


http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/neta....
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