Biotech Values

[iwfal]

the fact that drugs aren't approved on that basis doesn't make the question unrealistic

You are equating lack of evidence with evidence of lack - which is a logical fallacy so common it must have a name.

Find me a drug for a non-fatal disease that was submitted with two trials - one with p<0.01 and one with p between 0.05 and 0.10 - that was rejected in the last 3 years. Then I'll admit you might have a strong case.