Dendreon Corp fka DNDNQ

[iwfal]

How much of the shortfall in log rank p-value and HR is attributable to smaller size?

Very little. Trial size was only a small contributor.

The two biggest 'known' contributors were probably sicker population and imbalance. But there is probably something else going on as well - the imbalance probably isn't as severe as the published CR would lead one to believe.

If 9902B mirrors the combined 9901/9902A results, what might the results of 9902B using the SPA prespecified cox analysis look like at the interim and final?

My guess is that it is stat sig - but just barely. The reason that it is just barely is the effect that Ego brought up - the HR at less than 2 years is pretty low even with exactly the same patient pop as in 9901/2a. Remember that 9901/2a was p=0.011 at everyone 3 years. 02b will be only a few more deaths - but probably more than 50% of them will be at less than 2 years since randomization. So ...