Red rice yeast and lovastatin.
The Chinease have used red rice yeast in food for centuries because they like the taste. It had also been claimed to be healthy for the heart (seams like all rare/unusal foods have such claims).
Well, turns out that it contained lovastatin. So the claims that it lowers cholosterol were reasonably well grounded. But as health food vendors started pushing this big time, the FDA stepped in and banned it (it is now back, after several court orders and theroetically processed to exclude the statin).
If I am not mistaken, statins as a class are the largest revenue drug.
Now, this is not a solid comparison to PreHist and B12, but there are similarities.
The importatnt point is that the FDA did act against a real food ingrediant (while cyaoncobalamin is NOT in any naturaly food).
Of course the FDA will continue to allow vitamin pills containing B12 in the cyano- form, but any hint of advertising high dose orally absorbed cyancobalim for preventing hey fevors will get their ire up.