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Re: egomaniakos post# 3537

Tuesday, 05/15/2007 10:06:35 AM

Tuesday, May 15, 2007 10:06:35 AM

Post# of 12660
I believe you are omitting the fact that in the interim analysis the p value will be heavily influenced by the 180 or so patients who are much earlier in their course where the curve separation is much less.

A interesting comment. IF(!) the 9902b patient population is the same as the 9901/2a population then HR in the early parts of the curve is pretty low - by 2008 you might expect perhaps 20-25% of the population to have made it to 3 years or more. And 50% to be 2 years or less - where the HR is 1.2 to 1.3 in the 9901/2a combo.

Given that I suspect that the patient population is actually sicker in 9902b (albeit perhaps not too much given the company's assertion that the nomogram survival was similar) I would actually expect lower HRs than in blended 9901/2a?
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