Wise Investments

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PVCT news..................

KNOXVILLE, Tenn., Dec 16, 2003 /PRNewswire-FirstCall via Comtex/ --

Provectus Pharmaceuticals, Inc. (OTC Bulletin Board: PVCT) announced today that it is offering for sale up to approximately 1 million U.S. dollars of its restricted common stock. The transaction is a Regulation S offering to foreign investors as defined by Regulation S of the Securities Act of 1933, as amended (the 'Securities Act'). The restricted shares cannot be traded for 12 months. After the first 12 months, sale of the shares are subject to restrictions under Rule 144 for an additional year. The company has engaged a placement agent to assist it in the offering.

'This funding, if successful, will allow us to further advance our ethical oncology and dermatology therapies and support production and sales of the Company's line of over-the counter products'said Provectus CEO, Craig Dees, Ph.D.

Provectus Pharmaceuticals Inc. licenses and sells products in three sectors of the health-care industry: 1)-prescription medications and treatment, 2) medical devices, and 3) over-the-counter (OTC) pharmaceuticals. Prescription drug products and devices treat diseases of the skin and many types of cancer. OTC products address complementary markets, primarily those involving skin care and comfort.

This news release is not an offer to sell or the solicitation of an offer to buy the common stock discussed herein. The common stock being issued in this offering has not been registered under the Securities Act and may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Securities Act. The company has not agreed to file a registration statement covering the offer and sale of the shares.

The company's offices and laboratory are located at 7327 Oak Ridge Highway, Suite A Knoxville, TN 37931; telephone: [phone]. For more information, contact the company at [e-mail] or visit the corporate Web site: www.pvct.com .