Erbitux, safety issues
If this one of the SOC's, then it appears that new and safer drugs need to be brought to market as these side effects are terrible and the safety profile imho is suspect at best...once again imho only.
My feeling is that as regards AEs, in practice it doesn't matter much whether a therapy is highly targeted or not, for the simple reason that the sponsors simply crank up the dosage until they can't crank it up any more. Rare exceptions are where complete inhibition of all the targets occurs before the DLT is reached. But with 'dirty' drugs which hit several targets with various efficiencies, that just ain't gonna happen.
micro
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