Entremed (ENMD)

[C_Peptide]

Heck, George, I'd try Panzem with chicken soup.

However, with respect to your citation of the article that shows mithramycin modulates the activity HSD17B2 through the SP1 transcription factor, which presumably would allow Panzem to remain active and unmetabolized longer, it is worth some study, but SP1 is a transcription factor that affects many genes, both pro-tumor and anti-tumor. I would rather see a combination with a direct inhibitor of HSD17B2, similar to the combination of levodopa+carbidopa in Parkinson's Disease or curcumin+piperine. In fact, I suspect panzem+piperine might be quite good at increasing the bioavailability of Panzem by inhibiting glucuronidation but the gut. (Besides, most cancer patients don't have an endometrium, at least not an active one.)

Best Regards,
C-Peptide