Let's go back to one of the paragraphs in the article:
"The Principle attributes coding- and non-coding DNA a mutually supportive role in which neither is inferior to the other, thereby changing Genomics from a fishing expedition for fewer and fewer genes into an Information Challenge of colossal proportions to decipher the genetic code in which both "coding" and "non-coding" DNA play an essential part."
According to the principle it is not a case of coding DNA interpreting non-coding DNA, as both are involved in a dualistic (contravariant to borrow a technical term from the article) role. Hence the additional complexity leading to a "challenge of colossal proportions".
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