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biophud

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biophud

Re: DewDiligence post# 42876

Friday, 03/09/2007 9:08:52 AM

Friday, March 09, 2007 9:08:52 AM

Post# of 252711
Dew--Are there other companies out there that are pursuing alternative ways to restore p53 function? I seem to recall several big pharma groups (Pfizer?, Roche?) looking at small molecules that potentiate the growth inhibitory effect of p53. I think the idea is to modulate proteins that promote p53 degradation (e.g. MDM2) and restore mutant p53 function. Not sure if any of these are in clinical trials.

biophud
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