RespireRx Pharmaceuticals Inc (RSPI): ALS targets motoneurons because they lac...

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Re: striaterminalis post# 4448

Thursday, 03/08/2007 7:44:06 PM

Thursday, March 08, 2007 7:44:06 PM

ALS targets motoneurons because they lack Ca chelators (calbindin, calretinin,...), making them particularly sensitive to unregulated Ca influx. Because of their unique sensitivity, what works for other neuron populations may not work at all for ALS.

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