I don't expect gene therapy for AMD to gain much traction for the reasons you mentioned and, more fundamentally, because AMD is the kind of multifactorial disease that is inherently challenging for gene therapy.
I commented on this nine years ago in #msg-113278211; gene therapies have doubtless improved since then, but the issue still pertains, IMO.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”
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