Rezolute Inc. (RZLT)

[Whalatane]

Co says to expect 6-12 mths to see improvement .
There are risks with anti VEGF shots ...and long term compliance is not that great

Anti-VEGF (anti-vascular endothelial growth factor) injections into the eye are commonly used to treat various retinal diseases like age-related macular degeneration, diabetic retinopathy, and retinal vein occlusions. While generally safe and effective, these injections can lead to certain complications:
Ocular Complications
Intraocular Inflammation/Endophthalmitis: There is a small risk of developing intraocular inflammation or endophthalmitis (severe intraocular bacterial infection) after the injection procedure.
Retinal Detachment/Tears: Intravitreal injections carry a risk of causing retinal tears or detachments, though the incidence is low.
Intraocular Hemorrhage: Subconjunctival hemorrhage can occur in around 10% of injections. Rare cases of massive subretinal or choroidal hemorrhages have also been reported.
Increased Intraocular Pressure (IOP): Studies show a significant portion (3.5-11%) of patients experience sustained IOP elevation after repeated anti-VEGF injections, potentially due to outflow obstruction or trabecular meshwork damage.
Silicone Oil Droplets: Silicone oil microdroplets can dislodge from the syringes used and accumulate in the vitreous, causing floaters and visual disturbances.
Systemic Complications
Thromboembolic Events: Though not conclusively proven, there are concerns that suppression of systemic VEGF levels by the injected anti-VEGF drugs could increase the risk of arterial thrombotic events like stroke or myocardial infarction.
Hypertension: Systemically administered anti-VEGF drugs are known to raise blood pressure by reducing vascular permeability. This risk with intravitreal injections is unclear.
While the overall safety profile is good, close monitoring for potential complications, especially IOP elevation, is recommended for patients receiving repeated anti-VEGF injections.

I think theres concern re repeat injections over time

Kiwi