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Monday, May 13, 2024 5:42:05 PM
Brilacidin is a synthetic, nonpeptidic, small molecule mimetic of defensin, a type of host defense proteins/peptides (HDPs) or antimicrobial peptides (AMPs)
So what's AMP/HDPs good for?
Antimicrobial peptides (AMPs) and host defense peptides (HDPs) are examples of membrane-active compounds with enhanced affinity for the negatively charged prokaryotic membranes with strong electrical potential gradients as prerequisites for cellular entry or direct disruption of the bacterial cell membrane. (6,7) These peptides are the first line of defense in many multicellular organisms and possess a broad range of biological activities, including antibacterial, antifungal, antiviral, anticancer, antiplasmodial, antiprotistal, insecticidal, spermicidal, and immunomodulatory activities.
Despite so many advantages, peptide antibiotics have had relatively little clinical success largely due to their in vivo toxicity, limited bioavailability, and large production costs.
Not so with Brilacidin with its low toxidity and cheap production costs. I really hope at some point Brilacidin's huge scientific bofy of evidence will eventually overpower the massive incompetence of our CEO.
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