UniCycive Therapeutics Inc (UNCY)

[Whalatane]

RMB. OLC is the bioequivlent of Fosrenol ( Lanthanum Carbonate ). . My wife has a few patients on Fosrenol .
The history with Lanthanum is roughly as follows ...from a large trial in China

The incidence of AEs was not significantly different between lanthanum carbonate and placebo during the maintenance phase.
The compliance of the present patients to the experimental drugs was quite good.
Compared with previous double-blind reports, lanthanum carbonate was better tolerated in the present study.
The present withdrawal rate during the titration and maintenance phases was the lowest, at only 10.8% and 6.2%, respectively (

So the highest drop out time is during titration .. while .increasing the dose to lower serum phosphorous to the target level with time of trial .
Based on trial history I'm sure they will be going as slow as possible to get to goal within trial design.

Lanthanum Carbonate has more side effects ( nausea etc ) when swallowed whole ...Fosrenol ..brand name ..is chewed or in powder form .

Ideally the drop out rate due to side effects will be at most 10% ...preferably less

Kiwi