Biotech Values

[mouton29]

I see your point, I don’t know what concentration is reached at the cornea and 26 micrograms of active ingredient sounds small but it’s roughly the size of an eyedrop. (I know this as I instill my glaucoma meds with a micropipette set at 12 mcg). And a bimatoprost eyedrop is .03% active ingredient, so 26 mcg is about 900 x the active ingredient in one drop. Of course, it’s released over about 180 days.

At the same time, if the concentration is so high, why was the lower dose in the trial ineffective?