Innovation Pharmaceuticals Inc (IPIX)

[frenchbroad]

Brilacidin makes a new drug more powerful to kill fungus. The team in Brazil continue their work. Preprint published today.
https://www.biorxiv.org/content/10.1101/2024.04.05.588305v1.full.pdf
"Taken together, these results indicate that the combination BRI+IBX is fungicidal, can increase the membrane permeability, has increased fungicidal activity in the presence of A549 lung epithelial cells, and wholly overcomes CAS resistance in echinocandin-resistant A. fumigatus clinical isolates and VOR resistant isolates. In summary, our work with BRI+IBX brings an essential contribution to the combination therapies already proposed for IBX, such as IBX+voriconazole, IBX+isavuconazole, and IBX+amphotericin that were synergistic against both A. fumigatus azole-susceptible and –resistant strains18-20. We extended the previously observed number of antifungal drugs BRI can potentiate against A. fumigatus."