Yes, some chemotherapeutic drugs can cause Epstein-Barr virus (EBV) infection in latently infected cells. These drugs include: Gemcitabine, Doxorubicin, Cis-platinum, and 5-fluorouracil. EBV can also be reactivated by drug-induced hypersensitivity syndrome (DRESS), which is a severe reaction to certain drugs. DRESS is characterized by: Fever, Skin eruption, Cervical lymphadenopathy, Leukocytosis with atypical lymphocytosis and/or eosinophilia, and Liver dysfunction. Anticonvulsants and antimicrobial agents are some drugs that can cause DRESS. For example, allopurinol and carbamazepine have been associated with EBV reactivation. Some drugs can also inhibit EBV replication in vitro, including: Acyclovir, Desiclovir, Ganciclovir, Interferon-alfa, Interferon-gamma, Adenine arabinoside, and Phosphonoacetic acid.
Medscape Reference Pediatric Mononucleosis and Epstein-Barr Virus Infection ... 3 days ago — Class Summary. Numerous drugs inhibit Epstein-Barr virus replication in vitro. These include acyclovir, desciclovir, ganciclovir, interferon-alfa, interferon-gamma, adenine arabinoside, and phosphonoacetic acid. Acyclovir, which inhibits viral shedding from the oropharynx, is the only antiviral drug used to treat infectious mononucleosis in placebo-controlled clinical trials. However, the clinical course is not significantly affected in patients with uncomplicated infectious mononucleosis.
EBV is best known for causing mononucleosis , but it can also lead to other diseases, including: Ear infections and diarrhea in children Guillain-Barre syndrome Certain cancers, including Burkitt's lymphoma and cancers of the nose and throat Post-transplant lymphoproliferative disease (PTLD)
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So if you have a 90% chance of having latent EBV why would you or your physician risk these drugs?
I speak from experience - I was poisoned by Cipro, a fluroquinolone. I died.... and I was given this lethal antibiotic for a FUNGAL INFECTION.
Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation Jae Yong Chang and Soo-Chan Kim corresponding author
We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein-Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and anti-EBV nuclear antigen IgG antibodies. To our knowledge, only one case of drug hypersensitivity syndrome (DHS) associated with EBV has been reported in the English-language literature. Our case is the second report of EBV-associated DHS, which suggests that EBV infection may contribute to the pathogenesis of AHS in a few patients.
